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Recent Research Articles

- 2012 -

LTP requires a reserve pool of glutamate receptors independent of subunit type.

Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA.

Nature. 2012 Dec 12.


Dimerization of postsynaptic neuroligin drives synaptic assembly via transsynaptic clustering of neurexin.

Shipman SL, Nicoll RA.

PNAS. 2012 Nov 20;109(47):19432-7


Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW.

PNAS. 2012 Nov 20;109(47):19426-31.

SAP102 Mediates Synaptic Clearance of NMDA Receptors.

Chen BS, Gray JA, Sanz-Clemente A, Wei Z, Thomas EV, Nicoll RA, Roche KW.

Cell Rep. 2012 Nov 29;2(5):1120-8.


A subtype-specific function for the extracellular domain of neuroligin1 in hippocampal LTP.

Shipman SL, Nicoll RA.

Neuron. 2012 Oct 18;76(2):309-16.


- 2011 -

Probing TARP modulation of AMPA receptor conductance with polyamine toxins.

Jackson AC, Milstein AD, Soto D, Farrant M, Cull-Candy SG, Nicoll RA.

J Neurosci. 2011 May 18;31(20):7511-20.

Functional dependence of neuroligin on a new non-PDZ intracellular domain.

Shipman SL, Schnell E, Hirai T, Chen BS, Roche KW, Nicoll RA.

Nat Neurosci. 2011 Jun;14(6):718-26.

Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.

Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI.

J Neurosci. 2011 Mar 30;31(13):5067-77.


Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1.

Lu W, Isozaki K, Roche KW, Nicoll RA.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22266-71.

Metabolic control of vesicular glutamate transport and release.

Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y.

Neuron. 2010 Oct 6;68(1):99-112.

Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.

Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16315-9.

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.

Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA, Jentsch TJ.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10232-7.

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH.

Neuron. 2010 Jan 14;65(1):66-79.

The role of SAP97 in synaptic glutamate receptor dynamics.

Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3805-10.

Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.

Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3799-804.


- 2009 -

TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains.

Milstein ADNicoll RA.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11348-51.


The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type.

Shi Y, Lu W, Milstein ADNicoll RA.

Neuron. 2009 Jun 11;62(5):633-40.


Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.

Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA.

Neuron. 2009 Apr 30;62(2):254-68.


Recent Reviews/Previews



Thinking outside the synapse: glycine at extrasynaptic NMDA receptors.

Gray JA, Nicoll RA.

Cell. 2012 Aug 3;150(3):455-6.


Stargazing from a new vantage--TARP modulation of AMPA receptor pharmacology.

Jackson ACNicoll RA.

J Physiol. 2011 Dec 15;589(Pt 24):5909-10.


Genetic analysis of neuronal ionotropic glutamate receptor subunits.

Granger AJ, Gray JA, Lu WNicoll RA.

J Physiol. 2011 Sep 1;589(Pt 17):4095-101.